资源与环境微生物技术

张伟欣

副教授
硕士生导师
个人简介 科研项目 学术论文

教育背景

2006/09 - 2011/06 山东大学,微生物学,博士

2009/12-2011/02 德国马普生物物理研究所,分子生物学,联合培养博士

2002/09 - 2006/06 山东师范大学,生物科学,学士

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工作经历

起止时间 单位名称 专业技术职务

2017.9至今 山东大学微生物技术研究院 副教授

2012.2-2017.8 山东大学生命科学学院 讲师

2012.2-2014.2 山东大学化学与化工学院 师资博士后

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研究方向

1、丝状真菌蛋白质高效翻译合成的调控机制研究

2、高版本丝状真菌底盘细胞工厂构建

3、真菌基因表达调控机理研究

4、真菌生物活性物质的生物合成

科研项目

1、国家重点研发计划合成生物学重点专项《高版本工业丝状真菌底盘构建》子课题——工业丝状真菌里氏木霉蛋白质合成分泌的分子机制

2、国家自然科学基金面上项目 《转录辅抑制复合物Cyc8-Tup1在瑞氏木霉纤维素酶基因转录激活中的作用机制》

3.国家自然科学基金青年项目 《瑞氏木霉纤维二糖转运蛋白CBT1的结构功能及其在纤维素酶基因诱导表达中的作用机制》

4.山东省优秀中青年科学家奖励基金 《瑞氏木霉纤维二糖转运系统在纤维素酶诱导表达中的功能研究》

代表性论文

1.Wang L, Lv X, Cao Y, Zheng F, Meng X, Shen Y, Chen G, Liu W*, Zhang W*. A novel transcriptional regulator RXE1 modulates the essential transactivator XYR1 and cellulase gene expression in Trichoderma reesei. Appl Microbiol Biotechnol. 2019, 103(11):4511-4523.

2.Wang L, Yang R, Cao Y, Zheng F, Meng X, Zhong Y, Chen G, Zhang W*, Liu W*. CLP1, a Novel Plant Homeo Domain Protein, Participates in Regulating Cellulase Gene Expression in the Filamentous Fungus Trichoderma reesei. Frontiers in Microbiology. 2019, 10: 1700.

3.Wang X (#), Zhang W (#), Zhou H, Chen G, Liu W*. An extracytoplasmic function sigma factor controls cellulose utilization by regulating the expression of an outer membrane protein in Cytophaga hutchinsonii. Appl Environ Microbiol. 2019, 85(5).

4. Zhou Y, Song X, Li Y, Shi J, Shi W, Chen X, Liu W, Liu X, Zhang W*, Zhang Y*. Enhancing peptaibols production in the biocontrol fungus Trichoderma longibrachiatum SMF2 by elimination of a putative glucose sensor. Biotechnol Bioeng. 2019 Aug 12. doi: 10.1002/bit.27138.

5.Wang X, Han Q, Chen G, Zhang W*, Liu W. A Putative Type II Secretion System Is Involved in Cellulose Utilization in Cytophaga hutchisonii. Frontiers in Microbiology. 8, 1482.

6.Cao Y, Zheng F, Wang L, Zhao G, Chen G, Zhang W*, Liu W*. Rce1, a novel transcriptional repressor, regulates cellulase gene expression by antagonizing the transactivator Xyr1 in Trichoderma reesei. Mol Microbiol. 105(1):65-83.

7.Zhang W, Cao Y, Chen G, Liu W*. Identification of the structural determinants for efficient glucose transport via segment swapping between two fungal glucose transporters. RSC advances. 2017 7:25109-25117.

8.Yang T, Bu X, Han Q, Wang X, Zhou H, Chen G, Zhang W*, Liu W. A small periplasmic protein essential for Cytophaga hutchinsonii cellulose digestion. Appl Microbiol Biotechnol. 2016 Feb;100(4):1935-44.

9.Zhang W, Cao Y, Gong J, Bao X, Chen G, Liu W*. Identification of residues important for substrate uptake in a glucose transporter from the filamentous fungus Trichoderma reesei. Scientific reports 2015, 5:13829.

10.Kou Y, Xu J, Cao Y, Lv X, Zhao G, Chen G, Zhang W*, Liu W. 2014 Gluconolactone induces cellulase gene expression in cellulolytic filamentous fungus Trichoderma reesei. RSC advances 2014, 4, 36057-36063.

11.Zhang W, Kou Y, Xu J, Cao Y, Zhao G, Shao J, Wang H, Wang Z, Bao X, Chen G, Liu W*. Two Major Facilitator Superfamily Sugar Transporters from Trichoderma reesei and Their Roles in Induction of Cellulase Biosynthesis. J Biol Chem 2013, 288:32861-32872.

12. Zhang W, Xie B, Chen X, Dong S, Zhang X, Zhou B, Zhang Y*. Domains III and I-2{alpha}, at the entrance of the binding cleft, play an important role in cold adaptation of the periplasmic dipeptide-binding protein (DppA) from the deep-sea psychrophilic bacterium Pseudoalteromonas sp. strain SM9913. Appl Environ Microbiol. 2010 Jul;76(13):4354-61.