资源与环境微生物技术

佘群新

教授
博士/硕士生导师
053258631522
个人简介 科研项目 学术论文 其他介绍

教育背景

博士1988.10–1992.10 丹麦奥胡斯大学分子生物学

硕士1982.9–1985.10 中国南京农业大学农业微生物学

本科1978.9–1982.7 中国华中农业大学农业微生物学


工作经历

2018.11. 山东大学特聘教授

2011–2018 丹麦哥本哈根大学古菌研究中心主任

2005–2019 丹麦哥本哈根大学生物系终身副教授

2000–2004丹麦哥本哈根大学分子生物学研究院生物化学系科研副教授

1996–1999丹麦哥本哈根大学分子生物学研究院生物化学系科研助理教授

1992–1995丹麦科技大学微生物研究中心 博士后

1985–1988中国农业科学院油料作物研究所(武汉) 研究助理


研究方向

基因编辑及环境微生物学原理与技术

主要研究内容

1.CRISPR免疫体系的分子机制及CRISPR技术的开发与应用

2.肠道噬菌体及肠道微生物组的基因编辑原理的研究与技术的开发

3.极端微生物合成生物学、古菌细胞周期的调控


科研项目

1.2020.7-2025.6,极端微生物底盘细胞的设计与构建——课题负责人(课题2:耐热、耐酸微生物底盘细胞的设计构建与表征)

2. 2019.1-2020.12,转基因生物新品种培育国家科技重大专项——任务负责人(子课题:细菌和古菌的新型CRISPR体系的开发与应用)

3.2018.11-2023.10:山东大学特聘教授启动基金

4. 2018.1-2021.12:国家自然科学基金面上项目——项目负责人(冰岛硫化叶菌III-B型CRISPR-Cas系统靶标RNA激活DNase活性的分子机制)


学术论文

2015年以来的主要学术论文与专著

1.Q. She. 2021. Antiviral defense mechanisms in Archaea. InEncyclopedia of Virology 4th edition. Editors in Chief: Dennis Bamford and Mark Zuckerman. Volume 4: Viruses as Infectious Agents: Bacterial, Archaeal, Fungal, Algal, and Invertebrate Viruses, pp.400-406. Academic Press 2021(专著)

2.J. Lin, Y. Shen, J. Ni,Q. She.2021. A type III-A CRISPR-Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors.Nucleic Acids Res. 49, 7628-7643.

3. N. Sofos, M. Feng, S. Stella, T. Pape, A. Fuglsang, J. Lin, Q. Huang, Y. Li,Q. She, G. Montoya. 2020. Structures of the Cmr-Beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas."Mol Cell79,741-57 e7.

4. X. Feng, X. Liu, R. Xu, R. Zhao, W. Feng, J. Liao, W. Han,Q. She. 2020. A Unique B-Family DNA Polymerase Facilitating Error-Prone DNA Damage Tolerance in Crenarchaeota.Front Microbiol11 (2020): 1585.

5. J. Lin, M. Feng, H. Zhang,Q. She. 2020.Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase.Cell Discovery,6,29, https://doi.org/10.1038/s41421-020-0160-4.

6.R. Molina, S. Stella, M. Feng, N. Sofos, V. Jauniskis, I. Pozdnyakova, B. López-Méndez,Q. She and G. Montoya. 2019. Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.Nat Commun. 2019.10, 4302. doi: 10.1038/s41467-019-12244-z.

7.X. Feng, Q. Huang, and Q. She*.2019. Crenarchaeal 3D genome: A prototypical chromosome architecture for eukaryotes.Cell 179,56-58. doi: 10.1016/j.cell.2019.08.045

8. M. S. Donia, Q. She, J.A. Huber and H. Jia. 2019. Cell LeadingEdge Voices: Creating a Unique Culture.Cell 177,1368-1369. doi: 10.1016/j.cell.2019.05.014 (Voice piece by QS “Empathy as a solution”)

9. T. Guo, W. Han*, Q. She*. 2019. Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus.RNA Biol16,549-556. doi: 10.1080/15476286.2018.1460993.

10. W. Han, S. Stella, Y. Zhang, T. Guo, K. Sulek, L. Lundgren, G. Montoya, Q. She*. 2018. A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding.Nucleic Acids Res.46,10319-10330.

11. M. Sun, X. Feng, Z. Liu, W. Han, Y. X. Liang*, Q. She*. 2018. An Orc1/Cdc6 ortholog functions as a key regulator in the regulatory network of DNA damage response in an archaeon.Nucleic Acids Res.46,6697-6711.

12. X. Feng, M. Sun, W. Han, Y. X. Liang, Q. She*. 2018. transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea.Nucleic Acids Res.46,7085-7096.

13. W. Han, S. Pan, B. López-Méndez, G. Montoya and Q. She*. 2017. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail.Nucleic Acids Res.45,10740-10750.

14. Y. Li, Y. Zhang, J. Lin, S. Pan, W. Han, N. Peng, Y. X. Liang, Q. She*. 2017. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA.Nucleic Acids Res. 45, 11305-11314.

15. T. Liu, Z. Liu, Q. Ye, S. Pan, X. Wang, W. Peng, Y. Li, X. Y. Liang, Q. She, N. Peng. 2017. Coupling transcriptional activation of CRISPR-Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus.Nucleic Acids Res. 45, 8978-8992.

16. W. Han, Y. Xu, X. Feng, Y. X. Liang, L. Huang, Y. Shen. Q. She*. 2017. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus. Front Microbiol. doi:10.3389/fmicb.2017.01480

17. N. Peng, W. Han, Y. Li, Y. X. Liang, Q. She*. 2017.Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea. Sci China Life Sci. 60, 370-385.

18. W. Han, L. Deng, M. Feng, W. Peng, S. Hallstr?m, Y. X. Liang, M. F. White, Q. She*. 2017. A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction by modulating the cognate RNA cleavage. Nucleic Acids Res. 28, 1983-1993.

19. F. He, G. Vestergaard, W. Peng, Q. She, X. Peng. 2017. CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation.Nucleic Acids Res. 45, 1902-1913.

20. Q. She*, X. Feng and W. Han. 2017. Archaeal DNA damage repair. In Communication of Archaea, (G. Witzany, ed. 2017) pp305-318. Springer Publisher (专著)

21. Y. Li, S. Pan, Y. Zhang, M. Ren, M. Feng, N. Peng, L. Chen, Y. X. Liang*, Q. She*. 2016. Harnessing Type I and Type III CRISPR-Cas systems for genome editing. Nucleic Acids Res. 44, e34.

22. H. Wang, N. Peng, S. A. Shah, L. Huang*, Q. She*. 2015. Archaeal Extrachromosomal Genetic Elements.Microbiol. Mol. Biol. Rev.79,117-152. doi: 10.1128/MMBR.00042-14.

23. W. Peng, M. Feng, X. Feng, X. Y. Liang, Q. She*. 2015. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference. Nucleic Acids Res. 43, 406-417.

24. T. Liu, Y. Li, X. Wang, Q. Ye, H. Li, Y. X. Liang, Q. She, N. Peng. 2015. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition.Nucleic Acids Res. 43, 1044-1055.

25. S. Fusco S, Q. She, G. Fiorentino, S. Bartolucci, P. Contursi. 2015. Unravelling the role of the F55 regulator in the transition from lysogeny to UV induction of Sulfolobus spindle-shaped virus 1. J. Virol. 89, 6453-6461.

2003年:中国国家自然科学基金杰出青年基金(B类-国际合作)

2003年:The Danish Council of Technical Sciences: The Young Research Leaders Program(丹麦国家杰青)

2019年:Frontiers in Microbiology,Biology of Archaea,Asscoiate Editor

2019年:BMC Molecular and Cell Biology,Asscoiate Editor

2021年:Frontiers in Genome Editing, Genome editing Tools and Mechanisms, Specialty Chief Editor(栏目主编)