医药微生物技术

周海波

副研究员
硕士生导师
18253244344
个人简介 科研项目 学术论文 其他介绍

教育背景

博士2011.08-2016.06,中国海洋大学,医药学院,药物化学专业

学士2006.09-2010.07,河南中医学院(现河南中医药大学),药学院,制药工程专业

工作经历

起止时间? 单位名称? 专业技术职务

2022.03-至今山东大学微生物技术研究院副研究员

2018.11-2022.02山东大学微生物技术研究院助理研究员

2016.06-2018.10山东大学生命科学学院博士后

研究方向:

1.微生物天然产物结构多样性研究

2.活性天然产物生物合成机制解析及结构改造

3.特殊生境来源微生物资源挖掘

科研项目:

1. 2022/01-2024/12国家自然科学基金-青年基金项目,30万元,主持

2. 2021/01-2023/12山东省自然科学基金-青年基金项目,15万元,主持

3. 2019/04-2021/12山东大学基本科研业务费,10万元,主持

4. 2017/08-2019/12山东省自然科学基金-博士基金项目,8万元,主持

5.?2017/06-2019/06中国博士后科学基金-面上项目,5万元,主持

6. 2016/07-2018/06山东大学博士后日常经费,2万元,主持

学术论文

1.Qiyao Shen#,Haibo Zhou#, Guangzhi Dai, Guannan Zhong, Liujie Huo, Aiying Li, Yang Liu, Ming Yang, Vinothkannan Ravichandran, Zhihui Zheng, Ya-Jie Tang, Nianzhi Jiao, Youming Zhang, Xiaoying Bian *. Characterization of a Cryptic NRPS Gene Cluster inBacillus velezensisFZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis.ACS Catalysis.,2022, 12, 3371–3381.

2. Xue Wang#, Wentao Zheng#,Haibo Zhou, Qiang Tu, Ya-Jie Tang, A. Francis Stewart*, Youming Zhang*, Xiaoying Bian*. Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria.Nucleic Acids Research,2022, 50, e15.

3. Qiyao Shen, Guangzhi Dai, Aiying Li, Yang Liu, Guannan Zhong, Xiaoju Li, Xiangmei Ren, Haiyan Sui, Jun Fu, Nianzhi Jiao, Youming Zhang, Xiaoying Bian,Haibo Zhou*. Genome-Guided Discovery of Highly Oxygenated Aromatic Polyketides, Saccharothrixins D-M, from the Rare Marine ActinomyceteSaccharothrixsp. D09.J. Nat. Prod.,2021, 84, 2875-2884.

4. Qiyao Shen, Guangzhi Dai, Vinothkannan Ravichandran, Yang Liu, Lin Zhong, Haiyan Sui, Xiangmei Ren, Nianzhi Jiao, Youming Zhang*,Haibo Zhou*, Xiaoying Bian*. Saccharochelins A?H, Cytotoxic Amphiphilic Siderophores from the Rare Marine ActinomyceteSaccharothrixsp. D09.J. Nat. Prod.,2021, 84, 2149-2156.

5. Hanna Chen, Tao Sun, Xianping Bai, Jie Yang, Fu Yan, Lei Yu, Qiang Tu, Aiying Li, Yajie Tang, Youming Zhang*, Xiaoying Bian*,Haibo Zhou*. Genomics-Driven Activation of Silent Biosynthetic Gene Clusters inBurkholderia gladioliby Screening Recombineering System.Molecules.2021, 26(3), 700.

6. Yang Liu#,Haibo Zhou#, Qiyao Shen, Guangzhi Dai, Fu Yan, Xiaoju Li, Xiangmei Ren, Qin Sun,

Ya-Jie Tang, Youming Zhang, Xiaoying Bian*. Discovery of Polycyclic Macrolide Shuangdaolides by Heterologous Expression of a Cryptic trans-AT PKS Gene Cluster.Org. Lett.,2021, 23, 6967?6971.

7.周海波,申琪瑶,陈汉娜,王宗杰,李越中,张友明*,卞小莹*.利用异源表达挖掘纤维堆囊菌So0157-2的新型天然产物,合成生物学,2021, 2, 837-849.

8. Jiaqi Liu,Haibo Zhou, Zhiyu Yang, Xue Wang, Hanna Chen, Lin Zhong, Wentao Zheng, Weijing

Niu, Sen Wang, Xiangmei Ren, Guannan Zhong, Yan Wang, Xiaoming Ding, Rolf Müller, Youming Zhang, Xiaoying Bian*. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria.Nat. Commun.,2021, 12, 4347.

9. Lin Zhong#, Xiaotong Diao#, Na Zhang#, Fengwei Li;Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang*, Dalei Wu*, Xiaoying, Bian*. Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis.Nat. Commun.,2021, 12, 296.

10. Hanna Chen#,Haibo Zhou#, Tao Sun, Jiaying Xu, Qiang Tu, Jie Yang, Youming Zhang, Xiaoying Bian*. Identification of Holrhizins E?Q Reveals the Diversity of Nonribosomal Lipopeptides inParaburkholderia rhizoxinica.J. Nat. Prod.2020, 83, 537?541.

11.Zong-Jie Wang,Haibo Zhou, Guannan Zhong, Liujie Huo, Ya-Jie Tang, Youming Zhang*, Xiaoying Bian*. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Org. Lett.,2020, 22, 939?943.

12.Xue Wang#,Haibo Zhou#, Hanna Chen#, Xiaoshu Jing, Wentao Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Yue-Zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Müller, Xiaoying Bian*, Youming Zhang*. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proc. Natl. Acad. Sci. U S A,2018, 115, E4255-E4263.

13.Haibo Zhou, Xinhua Sun, Na Li, Qian Chen, Tianjiao Zhu, Qianqun Gu, Dehai Li. Isoindolone

Containing Meroperpenoids from the Endophytic FungusEmericella nidulansHDN12-249.Org. Lett.,2016, 18, 4670?4673.

14.Haibo Zhou#, Liyuan Li#, Chongming Wu, Tibor Kurta?n, Attila Ma?ndi, Yankai Liu, Qianqun Gu, Tianjiao Zhu*, Peng Guo*, Dehai Li*. Penipyridones A?F, Pyridone Alkaloids fromPenicillium funiculosum.J. Nat. Prod.,2016, 79, 1783?1790.

15.Haibo Zhou, Liyuan Li, Wei Wang, Qian Che, Dehai Li, Qianqun Gu, Tianjiao Zhu*. Chrodrimanins I and J from the Antarctic Moss-Derived FungusPenicillium funiculosumGWT2-24.J. Nat. Prod.,2015, 78, 1442?1445.

获奖情况:

2017年山东省优秀博士学位论文


专利:

1.卞小莹,王雪,陈汉娜,周海波,张友明.一组伯克氏菌同源重组酶及其表达载体与应用, ZL201710685563.2

2.朱天骄,周海波,李德海,顾谦群,郭鹏.一种吡啶酮生物碱类化合物及其制备方法和用途, ZL201410272489.8