医药微生物技术

王浩鑫

副教授
硕士生导师
0532-58631552
个人简介 科研项目 学术论文 其他介绍

教育背景

博士 起止时间:2001/9 - 2008/1

毕业院校:中国科学院昆明植物研究所

专业:植物学

学士 起止时间:1997/9 - 2001/7

毕业院校:安徽大学

专业:生物学

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工作经历

起止时间 单位名称 专业技术职务

2016/9 -至今 山东大学 副教授

2010/6 –2016.8 山东大学 讲师

2008/3 - 2010/3 厦门大学 博士后


研究方向

1.放线菌与“不可培养”微生物中新天然产物的理性挖掘与生物合成研究

2.基于生物合成/合成生物学的天然产物结构改造

3.天然产物活性与功能研究

科研项目

1.国家自然科学基金面上项目,31570039,定向挖掘含AHBA结构单元的新活性天然产物,2016/01?2019/12,65万元,在研,主持;

2.国家自然科学基金重点项目,81530091,安莎的新骨架发掘与药用功能导向的结构优化,2016.01-2020.12,273万元,在研,参加

3.国家自然科学基金海外及港澳学者合作研究基金,31329005,溶杆菌的抗水稻病原活性成分离和生物合研究,2014/01-2017/12,200万元,已结题,参加;

4.国家自然科学基金青年项目,31100079,从隐性基因簇中发现新安莎霉素,2012/01-2014/12,25万元,已结题,主持;

5. 973子课题,2012CB721005,药物合成途径解析与优化,2012/01-2016/10,89万元,已结题,参加;

代表性论文

?1.Y. Li,H. Wang, Y. Liu, Y. Jiao, S. Li, Y. Shen*, L. Du*(2018). "Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes" Angew Chem Int Ed Engl. accepted, DOI: 10.1002/anie.201802488.

2. G. Shi#; N. Shi#; Y. Li; W. Chen; J. Deng; C. Liu; J. Zhu;H. Wang*; Y. Shen*, d-Alanylation in the Assembly of Ansatrienin Side Chain is Catalyzed by a Modular NRPS. ACS chemical biology 2016, 11(4), 876-881.

3.S. Li; Y. Li; C. Lu; J. Zhang; J. Zhu;H. Wang*; Y. Shen*, Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains. Org Lett 2015, 17, 3706-9.

4.C. Liu; J. Zhu; Y. Li; J. Zhang; C. Lu;H. Wang*; Y. Shen*, In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp. LZ35. Chembiochem 2015, 16, 998-1007.

5.C. Xie; J. Deng;H. Wang*, Identification of AstG1, A LAL family regulator that positively controls ansatrienins production in Streptomyces sp. XZQH13. Curr Microbiol 2015, 70, 859-64.

6.J. Zhu; W. Chen; Y. Li; J. Deng; D. Zhu; J. Duan; Y. Liu; G. Shi; C. Xie;H. Wang*; Y. Shen*, Identification and catalytic characterization of a nonribosomal peptide synthetase-like (NRPS-like) enzyme involved in the biosynthesis of echosides from Streptomyces sp. LZ35. Gene 2014, 546, 352-8.

7.S. Li#;H. Wang#; Y. Li; J. Deng; C. Lu; Y. Shen*, Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35. Chembiochem 2014, 15, 94-102.

8.H. Wang; Y. Chen; L. Ge; T. Fang; J. Meng; Z. Liu; X. Fang; S. Ni; C. Lin; Y. Wu; M. Wang; N. Shi; H. He; K. Hong; Y. Shen, PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 2013, 115, 77-85.

9.C. Lu#; Y. Li#; J. Deng#; S. Li;H. Wang*; Y. Shen*, Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod 2013, 76, 2175-2179.

10.Y. Jiang#;H. Wang#; C. Lu; Y. Ding; Y. Li; Y. Shen, Identification and characterization of the cuevaene A biosynthetic gene cluster in Streptomyces sp. LZ35. Chembiochem 2013, 14, 1468-1475.

11.H. Wang; Z. Geng; Y. Zeng; Y. Shen, Enriching plant microbiota for a metagenomic library construction. Environ Microbiol 2008, 10, 2684-2691

所获专利

1. 王浩鑫,曾英,沈月毛,植物内生菌制备方法,2007.3.19-2027.3.19,专利号:ZL200710065724.4。