医药微生物技术

庞秀华

教授
博士/硕士生导师
0532-58631505/13969188792
个人简介 科研项目 学术论文

教育背景

博士:1996.9-2000.7;华中农业大学;生物化学与分子生物学

硕士:1989.9-1992.7;中国科学院武汉病毒研究所;病毒学

学士:1985.9-1989.7;山东师范大学;普通生物学

?

工作经历

起止时间 单位名称 专业技术职务?

2009.3-至今 山东大学 教授

2004.3-2009.12 University of Texas Health Science Center at Tyler (USA) Instructor, Research associate senior, Post-doc.

2001.5-2004.2 University of Nancy I (France), Post-doc.


研究方向

1. 放线菌的代谢调控及基础生物学

2.放线菌的资源挖掘与利用

3. 微生物的生物降解及应用

4.海洋微生物的酶及应用

科研项目

1,国家重点研发计划(2018YFC0310603),主持(子课题)

2,国家重点研发计划(2016YFA0601303),主持(子课题)

3,国家自然科学基金应急项目(31741001),主持

4,国家自然科学基金面上项目(31470165),主持

5,国家自然科学基金面上项目(81171540),主持

6,国家自然科学基金面上项目(81071328),主持

7,山东省自然科学基金面上项目(ZR2019MC062),主持

8,山东省自然科学基金面上项目(ZR2010HM007),主持

代表性论文

*:通讯作者

★Zhu Y, Wang J, Su W, Li A, andPang X*.2021. Effects of dual deletionofglnRandmtrAon the expression of nitrogen metabolism genes inStreptomycesvenezuelae. Microbial Biotechnology.

★Zhu Y, Zhang P, Lu T, Wang X, Li A, Lu Y, Tao M, andPang X*. 2021. Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions inStreptomyces. Environmental Microbiology 23(11):6907-6923.

★Liu M, Xu W, Zhu Y, Cui X, andPang X*. 2021.The response regulator MacR and its potential in improvement of antibiotic production inStreptomyces coelicolor. Current Microbiology 78 (10):3696-3707.

★Zhu Y, Lu T, Zhang J, Tao M, andPang X*. 2020.A novel XRE-family regulator that controls antibiotic production and development inStreptomyces coelicolor. Applied Microbiology and Biotechnology 104 (23):10075-10089.

★Zhu Y, Zhang P, Zhang J, Wang J, Lu Y, andPang X*. 2020.Impact on multiple antibiotic pathways reveals MtrA as a master regulator of antibiotic production inStreptomycesand potentially in other actinobacteria.Applied andEnvironmentalMicrobiology 86 (20): e01201-20.

★Zhu Y, Xu W, Zhang P, Zhao Z, Sheng D, Ma W, Zhang YZ, Bai L, andPang X*. 2020. A hierarchical network of four regulatory genes controls production of the polyene antibiotic Candicidin inStreptomycessp. FR-008.Applied andEnvironmentalMicrobiology 86 (9): e00055-20.

★Zhu Y, Zhang P, Zhang J, Xu W, Wang X, Wu L, Sheng D, Ma W, Cao G, Chen X, Lu Y, Zhang Y, andPang X*. 2019. The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes inStreptomyces coelicolor.MolecularMicrobiology 112 (1):29-46.

★Liu M, Zhang P, Zhu Y, Lu T, Wang Y, Cao, G, Shi M, Chen X, Tao M, andPang X*.2019.Novel Two-Component system MacRS is a pleiotropic regulator that controls multiple morphogenic membrane protein genes inStreptomyces coelicolor.Applied andEnvironmentalMicrobiology 85 (4): e02178-18.

★Lu T, Zhu Y, Zhang P, Sheng D, Cao G,Pang X*. 2018. SCO5351 is a pleiotropic factor that impacts secondary metabolism and morphological development inStreptomyces coelicolor.FEMS Microbiology Letter365 (17), fny150.

★Zhang P, Wu L, Zhu Y, Liu M, Wang Y, Cao G, Chen XL, Tao M,Pang X*. 2017. Deletion of MtrA inhibits cellular development ofStreptomyces coelicolorand alters expression of developmental regulatory genes. Frontiers in Microbiology8:2013(1-18).

★Cao G, Zhang P, Gu Y,Pang X*. 2017.Gene Over expression inStreptomyces hygroscopicusAssociated with DNA amplification. Current Microbiology 74:979-86.

★Zhao Z, Shi T, Xu M, Brock NL, Zhao YL, Wang Y, Deng Z,Pang X*, Tao M*. 2016. Hybrubins: Bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes.OrganicLETTERS 18(3):572-5.

★Cao G, Howard ST, Zhang P, Wang X, Chen XL, Samten B, andPang X*. 2015. EspR, a regulator of the ESX-1 secretion system inMycobacterium tuberculosis,is directly regulated by the two-component systems MprAB and PhoPR.Microbiology 161(3):477-489.

★Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, andPang X*. 2015.Production of the antibiotic FR-008/Candicidin inStreptomycessp. FR-008 is coregulated by two regulators, FscRI and FscRIV, from different transcription factor families.Microbiology161(3):539-552.

★Zhang P, Wu H, Chen XL, Deng Z, Bai L, andPang X*. 2014. Regulation of the Biosynthesis of Thiopeptide Antibiotic Cyclothiazomycin by a Transcriptiona1 Regulator SHJG8833 inStreptomyces hygroscopicus5008.Microbiology 160 (7):1379-1392.

Pang X*, Samten B, Cao G, Wang X, Tvinnereim A, Chen X, and Howard ST. 2013. MprAB regulates theespAoperon inMycobacterium tuberculosis, and modulates ESX-1 function and host cytokine response.Journal ofBacteriology 195(1):66-75.

Pang X, Howard ST. 2007. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system ofMycobacterium tuberculosis.Journal ofBacteriology 189(17):6213-21.

Pang X, Vu P, Byrd TF, Ghanny S, Soteropoulos P, Mukamolova GV, Wu S, Samten B, Howard ST. 2007. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant ofMycobacterium tuberculosis.Microbiology153(4):1229-42.

★Aigle B?,Pang X?, Decaris B, Leblond P. 2005. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the dupliated type II polyketide synthase alp gene cluster inStreptomyces ambofaciens.Journal ofBacteriology 187(7):2491-500.

Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P. 2004. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of theStreptomyces ambofacienslinear chromosome.AntimicrobialAgents andChemotherapy 48(2):575-88.

Pang X, Zhou X, Sun Y, Deng Z. 2002.Physical map of the linear chromosome ofStreptomyces hygroscopicus10-22 deduced by analysis of overlapping large chromosomal deletions.Journal ofBacteriology 184(7):1958-65.