医药微生物技术

尹贻贞

教授
博士/硕士生导师
个人简介 科研项目 学术论文

教育背景

2011.10-2015.03,日本九州大学药学府,创药科学专业,博士;

2008.09-2011.06,山东大学药学院,药物化学专业,硕士;

2004.09-2008.06,安徽医科大学药学院,药学专业,本科。


工作经历

2020.06-至今,山东大学微生物技术国家重点实验室(微生物技术研究院),教授

2019.05-2019.12,浙江工业大学绿色制药协同创新中心,校聘教授;

2018.09-2019.03,日本东京大学理学府,特任研究员;

2016.09-2018.08,日本东京大学理学府,日本学术振兴会(JSPS)外国人特别研究员;

2015.04-2016.08,日本东京大学理学府,特任研究员;


研究方向

1.基因编码非经典环肽库的生物法构建以及基于药物靶标的环肽筛选。

2. 人工核酸用于基因损伤修复机制以及抗肿瘤潜在应用的探讨。

科研项目

1. 山东大学“齐鲁青年学者”学科建设经费,2020.06-2025.05,主持。

2.国家青年自然科学基金,2020.01-2022.12,主持。

3. 日本学术振兴促进会(JSPS)外国人特别研究员奖励经费,2016.09-2018.08,主持。

代表性论文

1. Daisuke Hazama#,Yizhen Yin#, Yoji Murata*, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga*, Takashi Matozaki*. Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy.Cell Chem. Biol. 2020, DOI: https://doi.org/10.1016/j.chembiol.2020.06.008 (#共同一作)

2. Yizhen Yin, Fener Chen*. Targeting human MutT homolog 1 (MTH1) for cancer eradication: current status and perspectives.Acta Pharm. Sin. B 2020, DOI: https://doi.org/10.1016/j.apsb.2020.02.012

3. Yizhen Yin, Nobuaki Ochi, Timothy W. Craven, David Baker, Nagio Takigawa, Hiroaki Suga*. De novo carborane-containing macrocyclic peptides targeting human EGFR.J. Am. Chem. Soc. 2019,141, 19193–19197.

4. Yizhen Yin#, Qianran Fei#, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*. Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation.Angew. Chem. Int. Edit.2019,58, 4880–4885.

5. Alex Vinogradov,Yizhen Yin, Hiroaki Suga*. Macrocyclic peptides as drug candidates: recent progress and remaining challenges.J. Am. Chem. Soc. 2019,141, 4167–4181.

6.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation.Bioorg. Med. Chem.2016,24, 3856–3861.

7. Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.ChemBioChem 2016,17, 566–569.

8. Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Recognition and excision properties of 8-halogenated-7-deaza-2’-deoxyguanosine as 8-oxo-2’-deoxyguanosine analogues and Fpg and hOGG1 inhibitors.ChemBioChem 2015,16, 1190–1198.

9. Yizhen Yin, Yosuke Taniguchi*, Shigeki Sasaki*. Synthesis of 8-Halogena ted-7-deaza-2’-deoxyguanosine as an 8-Oxo-2’-deoxyguanosine Analogue and Evaluation of its Base Pairing Properties.Tetrahedron 2014,70, 2040–2047.

10.Yizhen Yin, Chao Liu, Long-Qian Tang, Zhao-Peng Liu*. Recoverable Pd/C catalyst mediated dehydrogenation of sterols and an improved synthesis of 1a-hydroxydehydroepiandrosterone.Steroids 2012,77, 1419–1422.

11. Yizhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang, Zhao-Peng Liu*. Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3 Analogues.Curr. Org. Synth. 2011,8, 374–392.

12. Bing-Lei Gao, Cheng-Mei Zhang,Yizhen Yin, Long-Qian Tang, Zhao-Peng Liu*. Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.Bioorg. Med. Chem. Lett. 2011,21, 3730–3733.