医药微生物技术

张正

研究员
博士/硕士生导师
0532-58631557
个人简介 科研项目 学术论文 其他介绍

教育背景

2014.09-2018.06,山东大学,微生物学,博士

2003.09-2007.06,山东大学,国家生命科学与技术人才培养基地,本科

工作经历

2021.01-至今,山东大学微生物技术研究院,研究员,“齐鲁青年学者”

2020.08-2021.01,山东大学微生物技术研究院,副研究员

2018.07-2020.07,山东大学微生物技术研究院,博士后

2007.07-2014.08,微生物技术国家重点实验室,科研助理

研究方向

1.基于生物信息大数据研究微生物进化机制

2.抗微生物毒素-免疫蛋白系统挖掘

3.原核生物功能基因的全球分布

1.山东大学“齐鲁青年学者”学科建设经费,2021-2026,主持

2.江苏省自然科学基金青年基金项目,2019-2022,主持

3.中国博士后基金特别资助,2018-2020,主持

4.中国博士后基金面上资助,2018-2020,主持

5.山东省博士后创新项目,2018-2020,主持

Zhang, Z.1*, Liu, Y.1, Zhang, P., Wang, J., Li, D., & Li, Y. Z.* (2021). PAAR Proteins Are Versatile Clips That Enrich the Antimicrobial Weapon Arsenals of Prokaryotes. mSystems, 6(6), e00953-21. (mSystems杂志同期专门发表了相关评论文章) (5 Year Impact Factor: 8.236)

Li, D. D., Wang, J. L., Liu, Y., Li, Y. Z.*, & Zhang, Z.* (2021). Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases. Computational and Structural Biotechnology Journal, 19, 5931. (5 Year Impact Factor: 7.409)

Feng, Z.1, Zhang, Z.,1 Liu, Y., Gu, J., Cheng, Y., Hu, W., Li, Y. Z., & Han, W.* (2021). The Second Chromosome Promotes the Adaptation of the Genus Flammeovirga to Complex Environments. Microbiology Spectrum, 9(3), e00980-21. (5 Year Impact Factor: 7.400)

Wang, J.1, Wang, J.1, Wu, S., Zhang, Z.*, & Li, Y. Z.* (2021). Global geographic diversity and distribution of the myxobacteria. Microbiology Spectrum, 9(1): e00012-21. (5 Year Impact Factor: 7.400)

Pan, Z., Zhang, Z., Zhuo, L., Wan, T., & Li, Y. Z.* (2021). Bioinformatic and Functional Characterization of Hsp70s in Myxococcus xanthus. mSphere, 6(3), e00305-21. (5 Year Impact Factor: 4.988)

Liu, Y., Wang, J., Zhang, Z., Wang, F., & Li, Y. Z.* (2021). Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in Myxococcus xanthus. Applied and Environmental Microbiology, 87(9): e00080-21. (5 Year Impact Factor: 5.260)

Zhang, Z.1*, Wang, J.1, Wang, J., Wang, J., & Li, Y. Z.* (2020). Estimate of the sequenced proportion of the global prokaryotic genome. Microbiome, 8(1), 1-9. (5 Year Impact Factor: 15.677)

Liu, Y., Zhang, Z.*, Wang, F., Li, D. D., & Li, Y. Z.* (2020). Identification of type VI secretion system toxic effectors using adaptors as markers. Computational and Structural Biotechnology Journal,18, 3723-3733. (5 Year Impact Factor: 7.409)

Zhang, P.1, Zhang, Z.1, Zhang, L., Wang, J., & Wu, C.* (2020). Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural features. Computational and Structural Biotechnology Journal, 18, 1383-1390. (5 Year Impact Factor: 7.409)

Wang, J., Wang, J., Zhang, Z., Li, Z., Zhang, Z., Zhao, D., ... & Li, Y. Z.* (2020). Shifts in the Bacterial Population and Ecosystem Functions in Response to Vegetation in the Yellow River Delta Wetlands. mSystems,5(3). (5 Year Impact Factor: 8.236)

Chen, X. J., Zhang, Z., Li, Y. J., Zhuo, L., Sheng, D. H., & Li, Y. Z.* (2020). Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02. FEMS Microbiology Ecology, 96(3), fiaa001. (5 Year Impact Factor: 5.137)

Li, D., Wang, J., Jin, Z., & Zhang, Z.* (2019). Structural and evolutionary characteristics of dynamin-related GTPase OPA1. PeerJ,7, e7285. (5 Year Impact Factor: 3.369)

Zhang, P., Zhang, Z., Li, Z. F., Chen, Q., Li, Y. Y., Gong, Y., ... & Li, Y. Z.* (2019). Phylogeny‐guided characterization of glycosyltransferases for epothilone glycosylation. Microbial Biotechnology,12(4), 763-774. (5 Year Impact Factor: 6.559)

Zhang, Z., Wang, J., Gong, Y., & Li, Y. Z.* (2018). Contributions of substitutions and indels to the structural variations in ancient protein superfamilies. BMC Genomics,19(1), 1-9. (5 Year Impact Factor: 4.478)

Gong, Y.1, Zhang, Z.1, Liu, Y., Zhou, X. W., Anwar, M. N., Li, Z. S., ... & Li, Y. Z.* (2018). A nuclease‐toxin and immunity system for kin discrimination in Myxococcus xanthus. Environmental Microbiology,20(7), 2552-2567. (5 Year Impact Factor: 6.438)

Zhuo, L., Zhang, Z., Pan, Z., Sheng, D. H., Hu, W., & Li, Y. Z.* (2018). CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms,1861(10), 928-937. (5 Year Impact Factor: 5.318)

Li, Y. J., Liu, Y., Zhang, Z., Chen, X. J., Gong, Y., & Li, Y. Z.* (2018). A post-segregational killing mechanism for maintaining plasmid pMF1 in its Myxococcus fulvus host. Frontiers in Cellular and Infection Microbiology, 8, 274. (5 Year Impact Factor: 5.882)

Gong, Y., Zhang, Z., Zhou, X. W., Anwar, M. N., H111u, X. Z., Li, Z. S., ... & Li, Y. Z.* (2018). Competitive interactions between incompatible mutants of the social bacterium Myxococcus xanthus DK1622. Frontiers in Microbiology,9, 1200. (5 Year Impact Factor: 6.320)

Yue, X. J.1, Cui, X. W.1, Zhang, Z., Hu, W. F., Li, Z. F., Zhang, Y. M., & Li, Y. Z.* (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Applied Microbiology and Biotechnology,102(13), 5599-5610. (5 Year Impact Factor: 4.697)

Gao, X.*, Zhang, Z.*, Li, Y., Zhu, H., Wang, S., & Li, C. (2017). A newly determined member of the meso-diaminopimelate dehydrogenase family with a broad substrate spectrum. Applied and Environmental Microbiology,83(11). (5 Year Impact Factor: 5.260)

Liu, L., Zhang, Z.*, Shao, C. L., & Wang, C. Y.* (2017). Analysis of the sequences, structures, and functions of product-releasing enzyme domains in fungal polyketide synthases. Frontiers in Microbiology,8, 1685. (5 Year Impact Factor: 6.320)

Yue, X. J., Cui, X. W., Zhang, Z., Peng, R., Zhang, P., Li, Z. F., & Li, Y. Z.* (2017). A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis. Microbial Cell Factories,16(1), 1-12. (5 Year Impact Factor: 5.588)

Zhuo, L.1, Wang, Y.1, Zhang, Z., Li, J., Zhang, X. H., & Li, Y. Z.* (2017). Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of groELs and groES. Frontiers in Microbiology,8, 733. (5 Year Impact Factor: 6.320)

Peng, R., Chen, J. H., Feng, W. W., Zhang, Z., Yin, J., Li, Z. S., & Li, Y. Z.* (2017). Error-prone DnaE2 balances the genome mutation rates in Myxococcus xanthus DK1622. Frontiers in Microbiology,8, 122. (5 Year Impact Factor: 6.320)

Wang, J., Zhang, Z.*, Chang, F., & Yin, D.* (2016). Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15. PeerJ, 4, e2079. (5 Year Impact Factor: 3.369)

Wang, J.1, Zhang, Z.1*, Liu, J., Zhao, J., & Yin, D.* (2016). Ectodomain architecture affects sequence and functional evolution of vertebrate toll-like receptors. Scientific Reports,6(1), 1-10. (5 Year Impact Factor: 5.133)

Liu, L., Zhang, Z.*, Shao, C. L., Wang, J. L., Bai, H., & Wang, C. Y.* (2015). Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains. Scientific Reports,5(1), 1-12. (5 Year Impact Factor: 5.133)

Wang, J.1, Zhang, Z.1*, Fu, H., Zhang, S., Liu, J., Chang, F., ... & Yin, D.* (2015). Structural and evolutionary characteristics of fish-specific TLR19. Fish & Shellfish Immunology,47(1), 271-279. (5 Year Impact Factor: 4.851)

Wang, J., Zhang, Z.*, Liu, J., Li, F., Chang, F., Fu, H., ... & Yin, D.* (2015). Structural characterization and evolutionary analysis of fish-specific TLR27. Fish & Shellfish Immunology,45(2), 940-945. (5 Year Impact Factor: 4.851)

Wang, Y.1, Zhang, W. Y.1, Zhang, Z., Li, J., Li, Z. F., Tan, Z. G., ... & Li, Y. Z.* (2013). Mechanisms involved in the functional divergence of duplicated GroEL chaperonins in Myxococcus xanthus DK1622. PLoS Genet,9(2), e1003306. (5 Year Impact Factor: 6.284)

Zhang, Z.1, Xing, C.1, Wang, L., Gong, B.*, & Liu, H. (2012). IndelFR: a database of indels in protein structures and their flanking regions. Nucleic Acids Research,40(D1), D512-D518. (5 Year Impact Factor: 15.542)

Zhang, Z., Huang, J., Wang, Z., Wang, L.*, & Gao, P. (2011). Impact of indels on the flanking regions in structural domains. Molecular Biology and Evolution,28(1), 291-301. (5 Year Impact Factor: 18.670)

Zhang, Z., Wang, Y., Wang, L.*, & Gao, P.* (2010). The combined effects of amino acid substitutions and indels on the evolution of structure within protein families. PLoS One, 5(12), e14316. (5 Year Impact Factor: 3.788)


Frontiers in Microbiology杂志Guest Associate EditorMicrobiome and Microbial Informatics专刊主编

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2021年Sino-Micro & ICMS年会Intestinal Microbiomes and Microbial Bioinformatics分会场主旨报告

2021年第五届微生物技术国家重点实验室青年人才学术交流会 优秀报告三等奖

2020年度山东大学微生物技术研究院“科研之星”