医药微生物技术

霍刘杰

教授
博士/硕士生导师
0532-58632596
个人简介 科研项目 学术论文 其他介绍

教育背景

德国萨尔大学/亥姆霍兹药物研究所,药物生物技术,博士学位

德国萨尔大学/亥姆霍兹药物研究所,药物生物技术,硕士学位

天津大学,生物工程,学士学位


研究工作经历

2017.10-至今,“齐鲁青年学者”特聘教授,微生物技术国家重点实验室,生命科学学院,山东大学

2014.09-2017.09,博士后,美国伊利诺伊大学香槟分校化学系


研究方向

1.微生物天然产物的生物合成

2.合成生物学改造优化微生物天然产物合成

3.基因组挖掘发现新型微生物天然产物

主持课题

2020.01-2024.12,国家重点研发计划子课题负责人,2019YFA0905702,在研,主持

2019.07-2024.06,国家重点研发计划子课题负责人,2018YFA0900400,在研,主持

2019.07-2022.06,山东省自然科学基金青年项目,ZR2019QC001,在研,主持

2018.07-2021.06,江苏省自然科学基金青年基金项目,BK20180228,在研,主持

2017.10-2022.10,山东大学齐鲁青年学者启动经费,主持

代表性论文

2020:

  1. Huo, L., Zhao, X., Acedo, J.Z., Estrada, P., Nair, S.K., and van der Donk, W.A. (2019). Characterization of a dehydratase and methyltransferase in the biosynthesis of a ribosomally-synthesized and post-translationally modified peptide in Lachnospiraceae.Chembiochem,doi: 10.1002/cbic.201900483.

  2. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.

    Wang ZJ, Zhou H, Zhong G,Huo L,Tang YJ, Zhang Y, Bian X., Org Lett. 2020 Feb 7;22(3):939-943. doi: 10.1021/acs.orglett.9b04490.

2019:

  1. Huo, L., Hug, J.J., Fu, C., Bian, X., Zhang, Y., and Müller, R. (2019).Heterologous expression of bacterial natural product biosynthetic pathways.Nat. Prod. Rep.,doi: 10.1039/c8np00091c.

  2. Bobeica, S.C., Dong, S.,Huo, L., Mazo, N., McLaughlin, M.I.H., Jimenez-Oses, G., Nair, S.K., and van der Donk, W.A. (2019). Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.eLife, 8:e42305,doi: 10.7554/eLife.42305.

  3. Chen, H., Bian, Z., Ravichandran, V., Li, R., Sun, Y.,Huo, L., Fu, J., Bian, X., Xia, L., Tu, Q., et al.(2019). Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales.Crit. Rev. Microbiol., 45, 162-181.doi: 10.1080/1040841X.2018.1514365.

2018:

  1. Wang, X., Zhou, H., Chen, H., Jing, X., Zheng, W., Li, R., Sun, T., Liu, J., Fu, J.,Huo, L., et al.(2018). Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proc. Natl. Acad. Sci. U S A, 115, E4255-E4263.doi: 10.1073/pnas.1720941115.

2017:

  1. Huo, L., ?kesli, A., Zhao, M., and van der Donk, W.A. (2017).Insights into the Biosynthesis of Duramycin.Appl. Environ. Microbiol., 17;83(3). e02698-16.,doi: 10.1128/AEM.02698-16.

  2. Gemperlein, K., Hoffmann, M.,Huo, L., Pilak, P., Petzke, L., Müller, R., and Wenzel, S.C. (2017).Synthetic biology approaches to establish a heterologous production system for coronatines.Metab. Eng., 44, 213-222.,doi: 10.1016/j.ymben.2017.09.009.

2016:

  1. Huo, L., and van der Donk, W.A. (2016). Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic.J. Am. Chem. Soc., 138, 5254-5257.doi: 10.1021/jacs.6b02513.

  2. Mukherjee, S.,Huo, L., Thibodeaux, G.N., and van der Donk, W.A. (2016). Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin.Org. Lett., 18, 6188-6191.doi: 10.1021/acs.orglett.6b03246.

  3. Mann, G.#,Huo, L.#(co-first), Adam, S., Nardone, B., Vendome, J., Westwood, N.J., Müller, R., and Koehnke, J. (2016). Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP.Chembiochem, 17, 2286-2292.doi: 10.1002/cbic.201600406.

2012:

  1. Huo, L., Rachid, S., Stadler, M., Wenzel, S.C., and Müller, R. (2012). Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis.Chem. Biol., 19, 1278-1287.doi: 10.1016/j.chembiol.2012.08.013.

  2. Barbie, P.,Huo, L., Müller, R., and Kazmaier, U. (2012).Stereoselective synthesis of deuterium-labeled (2S)-cyclohexenyl alanines, biosynthetic intermediates of cinnabaramide.Org. Lett., 14, 6064-6067.doi: 10.1021/ol3029548.

2011:

  1. Quade, N.#,Huo, L.#(co-first), Rachid, S., Heinz, D.W., and Müller, R. (2011). Unusual carbon fixation gives rise to diverse polyketide extender units.Nat. Chem. Biol., 8, 117-124.doi: 10.1038/nchembio.734.

  2. Rachid, S.,Huo, L., Herrmann, J., Stadler, M., Kopcke, B., Bitzer, J., and Müller, R. (2011).Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.Chembiochem, 12, 922-931.doi: 10.1002/cbic.201100024.

获奖

1.2012德国微生物协会(VAAM)年会最佳大会报告, Lecture Award.

2.2013欧洲微生物学会会议奖学金,Federation of European Microbiological Societies (FEMS) Meeting Attendance Grant.