医药微生物技术

高翔

教授
博士/硕士生导师
第周苑A座-319室
个人简介 科研项目 学术论文 其他介绍

课题组网站
??? gaolab.qd.sdu.edu.cn


教育背景

博士起止时间:2007/09-2012/06 毕业院校:清华大学专业:生物学

学士起止时间:2003/09-2007/06 毕业院校:山东大学 专业:生物科学


??? 工作经历

起止时间 单位名称 专业技术职务

2017/07?至今 山东大学 教授

2012/07?2017/07 耶鲁大学 博士后


研究方向

1. 病原微生物致病的分子机制。

2. 肠道病原微生物、肠道菌群以及宿主之间相互作用的分子机制。

科研项目

1. 肠道菌群互作,国家自然科学基金优秀青年科学基金项目,2022-2024,主持

2. 致病微生物Ⅲ型分泌系统结构与功能的研究,国家重点研发计划,政府间国际科技创新合作重点专项,2019-2022,主持

3. 沙门氏菌SopD效应蛋白家族功能的研究以及人伤寒沙门氏菌动物模型的优化,国家自然科学基金委面上项目,2018-2021,主持

4. 国家海外高层次人才青年项目,2017-2020,主持

5. 新型冠状病毒现场快速联合检测技术及装备开发,山东省重点研发计划,2020-2023,参加

6. 奶牛乳腺炎病学研究及新型疫苗研制,山东省自然科学基金重大基础研究项目,2019-2024,参加

7. 山东省泰山学者(青年项目),2017-2021,主持

8. 人体肠道微生物与人类健康,山东大学青年交叉科学创新群体,2020-2023,主持

9. 病原微生物的致病机制及抗感染药物的开发,山东大学国际科研合作种子基金,2019-2022,主持

(1)Huan Lian#, Kun Jiang#, Ming Tong#, Zhe Chen, Xiaoyu Liu, Jorge E. Galan*, and Xiang Gao* (2021)Salmonella Effector Protein SopD targets Rab8 GTPase to positively and negative regulate the inflammatory response. Nature Microbiology 6(3).(#, Co-first author)

(2)Kun Jiang#, Yan Zhang#, Zhe Chen#, Dalei Wu,Jun Cai and Xiang Gao* (2020) Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin of Bacillus thuringiensis. Toxins 12: 1-15. (#, Co-first author)

(3)Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki and Jorge E. Galan* (2017) Evolution of host adaptation in the Salmonella typhoid toxin.Nature Microbiology 12, 1592-1599.

(4)Yiqio Bao, Andrew A. Verdegaal, Brent W. Anderson, Natasha A. Barry, Jing He,Xiang Gao, Andrew L. Goodman (2021) A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria. mBio. 12(4): e00656-21.

(5)Peiyan Wang#, Siji Li#, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li,Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang* andFuping You*(2019) The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.J. Biol. Chem.294(45): 16494-16508.

(6)Lili Cao#, Shengde Liu#, Yunfei Li, Guang Yang, Yujie Luo, Siji Li, Hongqiang Du, Yingchi Zhao, Dandan Wang, Jingxuan Chen, Zeming Zhang, Mo Li, Songying Ouyang,Xiang Gao, Yujie Sun, Zekun Wang, Long Yang, Rongtuan Lin, Penghua Wang andFuping You*(2019) The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.Cell Host Microbe 26(3): 369-384.

(7)Casey Fowler, Shu-Jung Chang,Xiang Gao, Tobias Geiger, Gabrielle Stack andGalan, Jorge E*(2017)Emerging insights into the biology of typhoid toxin.Curr. Opin. Microbiol.35: 70-77. (invited review paper)

2017年之前发表文章

(1)Stefania Spanò#,Xiang Gao#, Sebastian Hannemann#, María Lara-Tejero and Jorge E. Galan* (2016) A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.Cell Host Microbe 19(2):216-26. (#, Co-first author)

(2)Lingquan Deng#, Jeongmin Song#,Xiang Gao#, Jiawei Wang, Hai Yu, Xi Chen, Nissi Varki, Yuko Naito-Matsui, Jorge Galan* and Ajit Varki* (2014) Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi.Cell 159(6):1290-9. (#, Co-first author)

(3)Jeongmin Song#,Xiang Gao#and Jorge E. Galan*(2013) Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.Nature 499(7458):350-4. (#, Co-first author; Highlighted by F1000)

(4)Xiang Gao#, Lijun Zhou#, Xuyao Jiao, Feiran Lu, Chuangye Yan, Xin Zeng, Jiawei Wang and Yigong Shi* (2010) Mechanism of substrate recognition and transport by an amino acid antiporter.Nature 463, 828-832. (#, Co-first author)

(5)Xiang Gao#, Feiran Lu#, Lijun Zhou#, Shangyu Dang, Linfeng Sun, Xiaochun Li, Jiawei Wang and Yigong Shi* (2009) Structure and Mechanism of an Amino Acid Antiporter.Science 324, 1565-1568. (#, Co-first author)

获奖情况

2015年获Blavatnik Regional Award Finalist

2014 年获James Hudson Brown - Alexander B. Coxe Fellowship

2011年获吴瑞奖


学术兼职

中国遗传学会微生物遗传专业委员会委员 2019-2023

中国病理生理学会系统生物学医学专委会委员 2019-2023